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IRAK1: A critical signaling mediator of innate immunity

โœ Scribed by Sridevi Gottipati; Navin L. Rao; Wai-Ping Fung-Leung


Book ID
113528132
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
385 KB
Volume
20
Category
Article
ISSN
0898-6568

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U1 RNA induces innate immunity signaling
โœ Robert W. Hoffman; Tal Gazitt; Mark F. Foecking; Robert A. Ortmann; Michael Misf ๐Ÿ“‚ Article ๐Ÿ“… 2004 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 237 KB

## Abstract ## Objective The U1โ€“70โ€kd RNP is a prominent target of autoimmunity in connective tissue diseases. In this study, we explored whether its endogenous ligand, U1 RNA, mediates a proimmune signal and may be immunogenic. ## Methods We assayed the proliferation of control and MyD88โ€knocko