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IRAK-4 as the central TIR signaling mediator in innate immunity

โœ Scribed by Nobutaka Suzuki; Shinobu Suzuki; Wen-Chen Yeh

Book ID
117787288
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
55 KB
Volume
23
Category
Article
ISSN
1471-4906

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## Background: Patients with ulcerative colitis are at increased risk for developing colorectal cancer. we have shown that toll-like receptor-4 (tlr4) is overexpressed in human colitis-associated cancer (cac) and that mice deficient in tlr4 are markedly protected against colitis-associated neoplasi