Identification of a genotoxic mechanism
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Marie StiborovΓ‘; MarkΓ©ta MikΕ‘anovΓ‘; Miroslav Ε ulc; Helena RΓ½dlovΓ‘; Heinz H. Schm
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Article
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2005
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John Wiley and Sons
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French
β 301 KB
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2-methoxyaniline (o-anisidine) is an industrial and environmental pollutant and a bladder carcinogen for rodents. The mechanism of its carcinogenicity was investigated with 2 independent methods, 32 P-postlabeling and 14 C-labeled o-anisidine, to show that o-anisidine binds covalently to DNA in vitr