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Ionic derivatives of betulinic acid as novel HIV-1 protease inhibitors

โœ Scribed by Zhao, Hua; Holmes, Shaletha S.; Baker, Gary A.; Challa, Suresh; Bose, Himangshu S.; Song, Zhiyan


Book ID
117996154
Publisher
Informa plc
Year
2011
Tongue
English
Weight
760 KB
Volume
27
Category
Article
ISSN
1475-6366

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Epsilon substituted lysinol derivatives
โœ Kristen L.G. Jones; M. Katharine Holloway; Hua-Poo Su; Steven S. Carroll; Christ ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 714 KB

A series of HIV-1 protease inhibitors containing an epsilon substituted lysinol backbone was synthesized. Two novel synthetic routes using N-boc-L-glutamic acid alpha-benzyl ester and 2,6-diaminopimelic acid were developed. Incorporation of this epsilon substituent enabled access to the S2 pocket of