✦ LIBER ✦

Ion-molecule reactions as probes of gas-phase structures of peptides and proteins

✍ Scribed by M. Kirk Green; Carlito B. Lebrilla

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 194 KB
Volume: 16
Category: Article
ISSN: 0277-7037
DOI: 10.1002/(sici)1098-2787(1997)16:2<53::aid-mas1>3.0.co;2-8

No coin nor oath required. For personal study only.

✦ Synopsis

A review with over 100 references describes the recent applicatures. Unlike collision-induced dissociation or collisiontions of ion-molecule reactions to the study of gas-phase protonally activated dissociation, which probe the primary strucated peptides and proteins. The topic is focused specifically on ture during collisional activation, ion-molecule reactions the proton transfer and hydrogen-deuterium exchange reactions are much gentler probes that provide information on the of amino acids, peptides, and proteins. A brief background is ions' secondary structure, often under the conditions of given of the various methods used for assigning proton affinities thermal equilibrium. Furthermore, ion-molecule reactions and gas-phase basicities. The methods used for measuring the can provide key information to help identify the intrinsic kinetics of deuterium incorporation of charged ion in the presfactors that determine gas-phase ion structures.

ence of a background pressure of deuterating reagents are also Gas-phase ion structure as a subject covers a broad described. Ion-molecule reactions are used to determine, among other things, the gas-phase basicities and proton affinities of * Dedicated to the memory of Professor R. W. Taft.

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