✦ LIBER ✦

Ion formation in MALDI mass spectrometry

✍ Scribed by Zenobi, Renato (author);Knochenmuss, Richard (author)

Publisher: John Wiley and Sons Inc.
Year: 1998
Tongue: English
Weight: 374 KB
Volume: 17
Category: Article
ISSN: 0277-7037
DOI: 10.1002/(sici)1098-2787(1998)17:5<337::aid-mas2>3.0.co;2-s

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✦ Synopsis

The origin of ions in matrix-assisted laser desorption/ionization (MALDI) mass spectrometry is currently a matter of active research. A number of chemical and physical pathways have been suggested for MALDI ion formation, including gas-phase photoionization, ion-molecule reactions, disproportionation, excited-state proton transfer, energy pooling, thermal ionization, and desorption of preformed ions. These pathways and others are critically reviewed, and their varying roles in the wide variety of MALDI experiments are discussed. An understanding of ionization pathways should help to maximize ion yields, control analyte charge states and fragmentation, and gain access to new classes of analytes.

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