✦ LIBER ✦

Ion channels as pharmacologic receptors: The chirality of drug interactions

✍ Scribed by David J. Triggle

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 347 KB
Volume: 8
Category: Article
ISSN: 0899-0042
DOI: 10.1002/(sici)1520-636x(1996)8:1<35::aid-chir8>3.0.co;2-f

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✦ Synopsis

Ion channels are pharmocologic receptors and as such exhibit stereoselective interactions with drugs. Ion channels are conformationally mobile transmembrane proteins existing in a number of open and closed states. Drug interactions with these Merent states may differ quantitatively and qualitatively. Stereoselectivity may not be a constant factor and may change according to channel state as determined by stimulus mode or experimental conditions. Selected examples are cited for Na+ and Ca2+ channels.

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