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Involvement of tumor necrosis factor-α in development of hepatic injury in galactosamine-sensitized mice

✍ Scribed by Ieharu Hishinuma; Jun-Ichi Nagakawa; Kazuo Hirota; Kaname Miyamoto; Kazuo Tsukidate; Takashi Yamanaka; Kou-Ichi Katayama; Isao Yamatsu

Book ID
102849769
Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
549 KB
Volume
12
Category
Article
ISSN
0270-9139

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✦ Synopsis

Intravenous injection of lipopolysaccharide and Dg a l a c t d e , at doses of 0.2 pg/kg and 800 mg/kg, respectively, elicited massive hepatic necrosis within 24 hr in C3HMeN mice. The plasma L-alanine aminotransferase (ALT, E.C. 2.6.1.2) or L-aspartate aminotransferase (AST, E.C. 2.6.1.1) activities at this point reached more than 2,000 IUL. However, overt hepatic injury as evaluated by the plasma aminotransferase activities did not develop in mice in which only lipoplysaccharide or only D-galactosamine was injected.

No tumor necrosis factolclike activities could be detected in the plasma of galactosarmn * e-and lipopolysaccharide-iqjected mice as determined by the assay of cytotoxicity to highly tumor necrosis factor-sensitive L-P3 cells through the experimental period of 24 hr.

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