✦ LIBER ✦

Involvement of toll-like receptor 4 in the inflammatory reaction induced by hydroxyapatite particles

✍ Scribed by Alexia Grandjean-Laquerriere; Olivier Tabary; Jacky Jacquot; Doriane Richard; Patrick Frayssinet; Moncef Guenounou; Dominique Laurent-Maquin; Patrice Laquerriere; Sophie Gangloff

Publisher: Elsevier Science
Year: 2007
Tongue: English
Weight: 145 KB
Volume: 28
Category: Article
ISSN: 0142-9612
DOI: 10.1016/j.biomaterials.2006.09.015

No coin nor oath required. For personal study only.

✦ Synopsis

Hydroxyapatite (HA) is widely used to coat metal parts in order to improve their biocompatibility. Analysis of retrieved tissues associated with failed implants, suggest that phagocytosis of HA wear debris by monocytes/macrophages might provide a potent stimulus for the release of a variety of cytokines. Phagocytosis involved a large variety of cellular receptors like toll-like receptors that results in activation of the transcriptional nuclear factor-kB (NF-kB) via a cell-signalling pathway. In the present paper, we aimed to evaluate the role of the toll-like receptor 4 (TLR4) in the production of inflammatory cytokines induced by HA particles using TLR4 + and TLR4 À peritoneal macrophages. We investigated the production of TNF-a and the activation of the nuclear transcription factor NF-kB. Our data clearly show for the first time that the production of TNF-a by macrophages exposed to HA particles was TLR4 dependent but not the activation of NF-kB. All these results open future therapies to reduce the inflammatory response induced by HA biomaterials.

📜 SIMILAR VOLUMES

Inhibition of toll-like receptor 4 break

Inhibition of toll-like receptor 4 breaks the inflammatory loop in autoimmune destructive arthritis

✍ Shahla Abdollahi-Roodsaz; Leo A. B. Joosten; Mieke F. Roelofs; Timothy R. D. J. 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 647 KB

Innate immune signaling by Toll-like rec

Innate immune signaling by Toll-like receptor-4 (TLR4) shapes the inflammatory microenvironment in colitis-associated tumors

✍ Masayuki Fukata; Yasmin Hernandez; Daisy Conduah; Jason Cohen; Anli Chen; Keith 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 831 KB

## Background: Patients with ulcerative colitis are at increased risk for developing colorectal cancer. we have shown that toll-like receptor-4 (tlr4) is overexpressed in human colitis-associated cancer (cac) and that mice deficient in tlr4 are markedly protected against colitis-associated neoplasi

Role of Toll-like receptor 4 in the infl

Role of Toll-like receptor 4 in the inflammation reaction surrounding silicone prosthesis

✍ Isabelle Auquit-Auckbur; Frédérique Caillot; Christophe Arnoult; Jean-François M 📂 Article 📅 2011 🏛 Elsevier Science 🌐 English ⚖ 857 KB

The inflammation which occurs around the silicone prosthesis is a complex process that can provoke the failure of the device and compromise the health of the implanted patient. Toll-like receptors (TLRs), which are transmembrane proteins, are now known to act in the innate immune response and in end

Toll-like receptors and chondrocytes: Th

Toll-like receptors and chondrocytes: The lipopolysaccharide-induced decrease in cartilage matrix synthesis is dependent on the presence of toll-like receptor 4 and antagonized by bone morphogenetic protein 7

✍ K. Bobacz; I. G. Sunk; J. G. Hofstaetter; L. Amoyo; C. D. Toma; S. Akira; T. Wei 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 586 KB

## Abstract ## Objective To assess the presence of Toll‐like receptors (TLRs) 1–9 in human articular cartilage, and to investigate the effects of lipopolysaccharide (LPS)–induced activation of TLR‐4 on biosynthetic activity and matrix production by human articular chondrocytes. ## Methods TLRs 1

Interactive role of the toll-like recept

Interactive role of the toll-like receptor 4 and reactive oxygen species in LPS-induced microglia activation

✍ Liya Qin; Guorong Li; Xun Qian; Yuxin Liu; Xuefei Wu; Bin Liu; Jau-Shyong Hong; 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 832 KB

## Abstract Microglia are activated by lipopolysaccharide (LPS) to produce neurotoxic pro‐inflammatory factors and reactive oxygen species (ROS). While a multitude of LPS receptors and corresponding pathways have been identified, the detailed mechanisms mediating the microglial response to LPS are

Selective priming to Toll-like receptor

Selective priming to Toll-like receptor 4 (TLR4), not TLR2, ligands by P. acnes involves up-regulation of MD-2 in mice

✍ Laszlo Romics Jr.; Angela Dolganiuc; Karen Kodys; Yvonne Drechsler; Shilpa Oak; 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 920 KB

Lipopolysaccharide (LPS) triggers cytokine production through Toll-like receptor 4 (TLR4), which shares downstream signaling pathways with TLR2. We investigated the roles of TLR2 and TLR4 in Propionibacterium acnes (P. acnes)-primed, LPS-induced liver damage using selective TLR ligands. Stock LPS in