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Inhibition of toll-like receptor 4 breaks the inflammatory loop in autoimmune destructive arthritis

✍ Scribed by Shahla Abdollahi-Roodsaz; Leo A. B. Joosten; Mieke F. Roelofs; Timothy R. D. J. Radstake; Giovanni Matera; Calin Popa; Jos W. M. van der Meer; Mihai G. Netea; Wim B. van den Berg


Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
647 KB
Volume
56
Category
Article
ISSN
0004-3591

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Hydroxyapatite (HA) is widely used to coat metal parts in order to improve their biocompatibility. Analysis of retrieved tissues associated with failed implants, suggest that phagocytosis of HA wear debris by monocytes/macrophages might provide a potent stimulus for the release of a variety of cytok