Involvement of Tis11b, an AU-rich binding protein, in induction of apoptosis by rituximab in B cell chronic lymphocytic leukemia cells
✍ Scribed by Baou, M; Jewell, A; Muthurania, A; Wickremasinghe, R G; Yong, K L; Carr, R; Marsh, P; Murphy, J J
- Book ID
- 109886712
- Publisher
- Nature Publishing Group
- Year
- 2008
- Tongue
- English
- Weight
- 152 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0887-6924
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B-cell chronic lymphocytic leukemia (B-CLL) is characterized by the slow and progressive accumulation of monoclonal apparently mature, CD5 ؉ B lymphocytes. The majority of circulating cells appear to be nondividing, and it has been suggested that a prolonged life span is mainly responsible for the a
## Abstract Signal transduction and apoptosis in B‐cell chronic lymphocytic leukemia (CLL) cells with a post‐germinal center (GC) phenotype were studied. Specific activation of the cells was induced by a combination of soluble anti‐CD40 monoclonal antibody and interleukin‐4 (CD40/IL‐4) and nonspeci