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Involvement of the amygdala in the effect of antidepressants on the passive avoidance deficit in bulbectomised rats

โœ Scribed by D. Garrigou; C. L. Broekkamp; K. G. Lloyd

Publisher
Springer
Year
1981
Tongue
English
Weight
618 KB
Volume
74
Category
Article
ISSN
0033-3158

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โœฆ Synopsis

In the present study the role of the amygdala is demonstrated in the effect of antidepressant drugs on passive avoidance learning in bulbectomised rats. Imipramine, amitriptyline, or fiuoxetine injected bilaterally (2 x 10 lag) into the medial part of the amygdala improves passive avoidance learning by bulbectomised rats. Systemic pretreatment with metergoline attenuates the effect of local imipramine or fluoxetine injection. Microinjection of serotonin but not noradrenaline into the amygdala improves passive avoidance learning by bulbectomised rats. The relevance of the amygdala in the behavioral effects of antidepressants in animals is discussed.

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