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Involvement of soluble receptor activator of nuclear factor-κB ligand (sRANKL) in collagenase-induced murine osteoarthritis and human osteoarthritis

✍ Scribed by Dimitrova, Petya; Toncheva, Antoaneta; Gyurkovska, Valeriya; Ivanovska, Nina


Book ID
113028803
Publisher
Springer
Year
2011
Tongue
English
Weight
704 KB
Volume
32
Category
Article
ISSN
0172-8172

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✍ Donatella Granchi; Ilaria Amato; Luca Battistelli; Sofia Avnet; Sergio Capacciol 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 550 KB

## Abstract Proliferation and differentiation of osteoclasts are regulated by a cytokine system that includes RANKL, which binds 2 receptors: RANK, which activates osteoclast differentiation, and osteoprotegerin (OPG), a decoy receptor that limits RANKL action. We investigated the role of the OPG/R