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Involvement of RhoA and possible neuroprotective effect of fasudil, a Rho kinase inhibitor, in NMDA-induced neurotoxicity in the rat retina

✍ Scribed by Yuka Kitaoka; Yasushi Kitaoka; Toshio Kumai; Tim T Lam; Kohei Kuribayashi; Kazuyuki Isenoumi; Yasunari Munemasa; Masamitsu Motoki; Shinichi Kobayashi; Satoki Ueno

Book ID
113499838
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
542 KB
Volume
1018
Category
Article
ISSN
0006-8993

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## Abstract ## Aims To investigate the concentration and activity of RhoA in detrusor and urothelium, as well as the effects of a Rho‐kinase inhibitor, Y‐27632 {(+)‐(R)‐trans‐4‐(1‐aminoethyl)‐N‐(4‐pyridyl) cyclohexanecarboxamide dihydrochloride}, on contraction of the pig urinary bladder. ## Meth