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Involvement of retinoblastoma protein in p27Kip1-induced apoptosis

✍ Scribed by Sangtaek Oh; Tae Kook Kim; Deog Su Hwang; Jeongbin Yim

Book ID
117469674
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
270 KB
Volume
148
Category
Article
ISSN
0304-3835

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## Abstract p27^kip1^ is a cyclin‐dependent kinase (CDK) inhibitor, which controls several cellular processes in strict collaboration with pRb. We evaluated the role of p27^kip1^ in paclitaxel‐induced apoptosis in the pRb‐defective SaOs‐2 cells. Following 48 h of exposure of SaOs‐2 cells to 100 nM