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Involvement of Protein Kinase C Activation in Endothelin-1-induced Secretion of Interleukin-6 in Osteoblast-like Cells

โœ Scribed by Mitsuhiro Matsuno; Osamu Kozawa; Atsushi Suzuki; Haruhiko Tokuda; Takehiro Kaida; Hiroyuki Matsuno; Masayuki Niwa; Toshihiko Uematsu

Book ID
114284086
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
197 KB
Volume
10
Category
Article
ISSN
0898-6568

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In a previous study, we have shown that endothelin-1 (ET-1) activates phospholipase D independently from protein kinase C in osteoblast-like MC3T3-E1 cells. It is well recognized that phosphatidylycholine hydrolysis by phospholipase D generates phosphatidic acid, which can be further degraded by pho