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Involvement of polyamines in iron(III) transport in human intestinal Caco-2 cell lines

✍ Scribed by Gérard Lescoat, Lucie Gouffier, Isabelle Cannie…


Book ID
120748577
Publisher
Springer
Year
2013
Tongue
English
Weight
382 KB
Volume
378
Category
Article
ISSN
0300-8177

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The transport of 10 amino acid ester prodrugs of levovirin (LVV) was investigated in the human intestinal Caco-2 cell line in order to overcome the poor oral bioavailability of LVV, an investigational drug for the treatment of hepatitis C infection. The prodrugs were designed to improve the permeabi