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Involvement of phagocytic microglia in increased vulnerability of motoneurons after facial nerve avulsion in presymptomatic ALS model rats

โœ Scribed by Sanagi, Tomomi; Ohsawa, Keiko; Nakamura, Yasuko; Suzuki, Eri; Aoki, Masashi; Warita, Hitoshi; Itoyama, Yasuto; Uchino, Shigeo; Kohsaka, Shinichi


Book ID
122595386
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
78 KB
Volume
68
Category
Article
ISSN
0168-0102

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Appearance of phagocytic microglia adjac
โœ Tomomi Sanagi; Shigeki Yuasa; Yasuko Nakamura; Eri Suzuki; Masashi Aoki; Hitoshi ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 969 KB

## Abstract Microglial activation occurs early during the pathogenesis of amyotrophic lateral sclerosis (ALS). Recent evidence indicates that the expression of mutant Cu^2+^/Zn^2+^ superoxide dismutase 1 (SOD1) in microglia contributes to the late disease progression of ALS. However, the mechanism