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Appearance of phagocytic microglia in facial nuclei after nerve avulsion in presymptomatic ALS model rats

✍ Scribed by Tomomi Sanagi; Shigeki Yuasa; Yasuko Nakamura; Masashi Aoki; Hitoshi Warita; Yasuto Itoyama; Shinichi Kohsaka; Keiko Ohsawa

Book ID: 116776752
Publisher: Elsevier Science
Year: 2009
Tongue: English
Weight: 95 KB
Volume: 65
Category: Article
ISSN: 0168-0102
DOI: 10.1016/j.neures.2009.09.353

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## Abstract Microglial activation occurs early during the pathogenesis of amyotrophic lateral sclerosis (ALS). Recent evidence indicates that the expression of mutant Cu^2+^/Zn^2+^ superoxide dismutase 1 (SOD1) in microglia contributes to the late disease progression of ALS. However, the mechanism