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Involvement of NMDA receptors in non-convulsive epilepsy in WAG/Rij rats

✍ Scribed by B.W.M.M. Peeters; C.M. Rijn van; J.M.H. Vossen; A.M.L. Coenen

Book ID
118344586
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
375 KB
Volume
47
Category
Article
ISSN
0024-3205

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CNQX, a new non-NMDA receptor antagonist
CNQX, a new non-NMDA receptor antagonist, reduces spike wave discharges in the WAG/Rij rat model of absence epilepsy
✍ G.M.J. Ramakers; B.W.M.M. Peeters; J.M.H. Vossen; A.M.L. Coenen πŸ“‚ Article πŸ“… 1991 πŸ› Elsevier Science 🌐 English βš– 330 KB

The effects on seizures, EEG and behavior of the non-NMDA receptor antagonist CNQX (6-cyano-7-nitroquinoxaline-2,3-dione), were studied in the WAG/Rij rat with absence epilepsy. Intracerebroventricular injections (10, 50, and 100 nmol/5 microliters CNQX) showed that CNQX decreases the number of spik