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Involvement of multiple cytochrome p450 isoforms in naproxen demethylation.

โœ Scribed by Tracy, T.S.; Marra, C.; Wrighton, S.A.; Gonzalez, F.J.; Korzekwa, K.R.

Book ID
110019607
Publisher
Nature Publishing Group
Year
1996
Tongue
English
Weight
117 KB
Volume
59
Category
Article
ISSN
0009-9236

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๐Ÿ“œ SIMILAR VOLUMES

Involvement of multiple cytochrome P450
Involvement of multiple cytochrome P450 isoforms in naproxen O-demethylation
โœ T. S. Tracy; C. Marra; S. A. Wrighton; F. J. Gonzalez; K. R. Korzekwa ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› Springer ๐ŸŒ English โš– 191 KB

## Objective: A series of studies was undertaken to determine the cytochrome p450 isoform(s) involved in naproxen demethylation and whether this included the same isoforms reported to be involved in the metabolism of other nsaids. ## Methods: (s)-naproxen was incubated with human liver microsomes