Involvement of mitochondrial permeability transition in acetaminophen-induced liver injury in mice
โ Scribed by Yasuhiro Masubuchi; Chieko Suda; Toshiharu Horie
- Book ID
- 116650507
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 259 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0168-8278
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Acetaminophen (APAP) is safe at therapeutic dosage but can cause severe hepatotoxicity if used at overdose. The mechanisms of injury are not yet fully understood, but previous reports had suggested that the mitochondrial permeability transition (mPT) may be involved in triggering hepatocellular necr
Acetaminophen toxicity is the most common cause of acute liver failure in the United States and Europe. Although much is known about the metabolism of acetaminophen, many questions remain regarding the pathogenesis of liver injury. In this study, we examined the role of lipopolysaccharide-binding pr