Involvement of lysine 1047 in type I collagen-mediated activation of polymorphonuclear neutrophils
✍ Scribed by Stéphane Jaisson; Hervé Sartelet; Corinne Perreau; Charlotte Blanchevoye; Roselyne Garnotel; Philippe Gillery
- Book ID
- 111312467
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 314 KB
- Volume
- 275
- Category
- Article
- ISSN
- 1432-1327
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## Abstract The discoidin domain receptor 1 (DDR1) is a receptor tyrosine kinase that is highly expressed in breast carcinoma cells. Upon binding to collagen, DDR1 undergoes autophosphorylation followed by limited proteolysis to generate a tyrosine phosphorylated C‐terminal fragment (CTF). Although