Involvement of insulin-like growth factor-insulin receptor signal pathway in the transgenic mouse model of medulloblastoma
β Scribed by Qiang Sun; Xiaoluan Wei; Jie Feng; Rong Zhang; Qian Shen; Juan Dong; Yujuan Jin; Suzhen Dong; Houda Li; Yinghe Hu
- Book ID
- 108584074
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 276 KB
- Volume
- 99
- Category
- Article
- ISSN
- 1347-9032
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## Abstract ## BACKGROUND High concentrations of insulinβlike growth factor (IGF)βI and IGFβII have been demonstrated in human colonic adenocarcinomas and exert mitogenic effects through paracrine/autocrine interactions with the IGFβI receptor (IGFβIR). However, definitive studies of IGFβIR expres