Involvement of gap junctional intercellular communication in the bystander effect induced by broad-beam or microbeam heavy ions

Stimulation of intercellular communicati

Stimulation of intercellular communication of poor-communicating cells by gap-junction-competent cells enhances the HSV-TK/GCV bystander effect in vitro

✍ Toshiaki Tanaka; Hiroshi Yamasaki; Marc Mesnil 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 French ⚖ 159 KB 👁 1 views

We have previously shown that gap-junctional intercellular communication (GJIC) appears to play a role in the bystander effect that is observed in anticancer suicide gene therapy mediated by herpes simplex virus (HSV) thymidine kinase (tk) and ganciclovir (GCV). We now report that when connexin-expr