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Involvement of dopamine receptors and β-arrestin in metamphetamine-induced inclusions formation in pc12 cells

✍ Scribed by Francesco Fornai; Paola Lenzi; Loredana Capobianco; Luisa Iacovelli; Pamela Scarselli; Gloria Lazzeri; Antonio De Blasi

Book ID
111180786
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
686 KB
Volume
105
Category
Article
ISSN
0022-3042

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## Abstract The effects of scoparone on dopamine biosynthesis and L‐DOPA‐induced cytotoxicity in PC12 cells were investigated. PC12 cells treated with scoparone at concentrations of 100–200 μM showed a 128–136% increase in dopamine levels over the course of 24 hr. Scoparone significantly increased