Involvement of Distinct Murine T-Cell Receptors in the Autoimmune Encephalitogenic Response to Nested Epitopes of Myelin Basic Protein
β Scribed by Koichiro Sakai, Animesh A. Sinha, Dennis J. Mitchell, Scott S. Zamvil, Jonathan B. Rothbard, Hugh O. McDevitt and Lawrence Steinman
- Book ID
- 123636277
- Publisher
- National Academy of Sciences
- Year
- 1988
- Tongue
- English
- Weight
- 857 KB
- Volume
- 85
- Category
- Article
- ISSN
- 0027-8424
- DOI
- 10.2307/32791
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Experimental autoimmune encephalomyelitis is a disease induced by neuroantigen-reactive T cells bearing particular types of T cell receptor (TCR). Although the nature of TCRs of encephalitogenic T cells has been partially delineated using encephalitogenic T cell clones established in vitro, the enti
T-cell receptor (TCR) β€-chain usage in experimental autoimmune encephalomyelitis (EAE) seems to be much more heterogeneous than previously assumed even for a single autoantigen in an inbred animal strain. Owing to the lack of suitable antibodies, this has been demonstrated only at the RNA level so f