Fluorescence lifetime analysis was used in combination with conventional flow cytometric analysis to monitor changes in residual chromatin in apoptotic HL-60 cell populations following treatment with camptothecin, cycloheximide, genistein, H7, and gamma radiation. Data presented show that all of the
✦ LIBER ✦
Involvement of CD45 in DNA fragmentation in apoptosis induced by mitochondrial perturbing agents
✍ Scribed by Philippe Desharnais; Geneviève Dupéré-Minier; Claudine Hamelin; Patrick Devine; Jacques Bernier
- Book ID
- 106349622
- Publisher
- Springer
- Year
- 2007
- Tongue
- English
- Weight
- 718 KB
- Volume
- 13
- Category
- Article
- ISSN
- 1360-8185
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DNA topoisomerase inhibitors are effective chemotherapeutic agents on several solid tumor cells. They induce a specific signaling cascade that executes an active cell death process (apoptosis), including caspase activation, and the blockage of the signaling is associated with drug-resistance of tumo