Involvement of caveolin-1 in 1α,25(OH)2-vitamin D3 regulation of c-Src, MAPK cascades, and VDR localization in skeletal muscle cells
✍ Scribed by C. Buitrago; R. Boland
- Book ID
- 116322560
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 58 KB
- Volume
- 45
- Category
- Article
- ISSN
- 8756-3282
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1,25-dihydroxy-vitamin D(3) (1,25(OH)(2)D(3)), the hormonally active form of vitamin D(3), acts through two different mechanisms. In addition to regulating gene expression via the specific intracellular vitamin D receptor (VDR), 1,25(OH)(2)D(3) induces rapid, non-transcriptional responses involving
We previously reported that 1a,25-dihydroxy-vitamin D 3 [1a,25(OH) 2 D 3 ] induces non-transcriptional rapid responses through activation of Src and MAPKs in the skeletal muscle cell line C2C12. In the present study we investigated the modulation of Akt by the secosteroid hormone in C2C12 cells at p