Involvement of carbohydrate moieties in the heterogeneities of human blood clotting factor IX
✍ Scribed by Benoǐt Polack; Jean-Marie Freyssinet
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- English
- Weight
- 376 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0173-0835
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The use of proteomic techniques in the monitoring of different production steps of plasma-derived clotting factor IX (pd F IX) was demonstrated. The first step, solid-phase extraction with a weak anion-exchange resin, fractionates the bulk of human serum albumin (HSA), immunoglobulin G, and other no
Mutations in Factor IX gene (F9) cause X-linked recessive bleeding disorder hemophilia B. Here, we characterized molecular events in nine North Indian hemophiliac families identifying four missense mutations (three novel), two nonsense mutations, and a deletion. We have also captured the mutational