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Involvement of Ca2+-independent phospholipase A2 in the translocation of hypoxia-inducible factor-1α to the nucleus under hypoxic conditions

✍ Scribed by Mayuko Osada-Oka; Minoru Takahashi; Satoshi Akiba; Takashi Sato


Book ID
113586400
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
334 KB
Volume
549
Category
Article
ISSN
0014-2999

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## Abstract The transcription factor hypoxia‐inducible factor‐1α (HIF‐1α) is the key regulator that controls the hypoxic response of mammalian cells. The overexpression of HIF‐1α has been demonstrated in many human tumors. However, the role of HIF‐1α in the therapeutic efficacy of chemotherapy and