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Involvement of c-Jun N-Terminal Kinase and p38 Mitogen-Activated Protein Kinase in α1B-Adrenergic Receptor/Gαq-Induced Inhibition of Cell Proliferation

✍ Scribed by Junji Yamauchi; Hiroshi Itoh; Hitomi Shinoura; Yuki Miyamoto; Akira Hirasawa; Yoshito Kaziro; Gozoh Tsujimoto


Book ID
115587555
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
143 KB
Volume
281
Category
Article
ISSN
0006-291X

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## Abstract A series of 42 naturally occurring flavonoids and one flavonoid glucuronide were tested for their ability to inhibit p38α mitogen‐activated protein kinase (p38α) and c‐Jun‐N‐terminal kinase 3 (JNK3). Potent inhibitors with IC~50~ values in the low micromolar range were identified. Struc