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Investigations on pyrazine derivatives. VII: On the conversion of pyrazine 2,5-dicarboxylic acid into some derivatives of 2-aminopyrazine 5-carboxylic acid

✍ Scribed by W. J. Schut; H. I. X. Mager; W. Berends

Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
445 KB
Volume
80
Category
Article
ISSN
0165-0513

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✦ Synopsis

Abstract

Pyrazine 2,5‐dicarboxylic acid was prepared by oxidation of 2,5‐dimethylpyrazine with selenium dioxide. 2,5‐Diethoxycarbonylpyrazine appeared to be a suitable starting‐material for the preparation of monocarbamoyl‐ and monocarboxyhydrazide derivatives. Hofmann degradation of 2‐carbamoyl‐5‐ethoxycarbonylpyrazine into 2‐aminopyrazine 5‐carboxylic acid proved to be rather difficult. The monocarboxyhydrazides in this series could be readily converted into acid azides and eventually into pyrazine‐urethanes.

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