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Investigations on pyrazine derivatives. VI. The reduction of 2,3,5,6-tetraethoxycarbonylpyrazine with alkaline sodium dithionite

✍ Scribed by H. I. X. Mager; W. Berends


Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
183 KB
Volume
79
Category
Article
ISSN
0165-0513

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✦ Synopsis


Abstract

A new convenient method is given for the preparation of 2,3,5,6‐tetraethoxycarbonyl‐1,4‐dihydropyrazine.


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✍ Yusaku Eda; Yuta Odazaki; Akira Mizutani; Yoshio N. Ito; Toshio Kawato 📂 Article 📅 2008 🏛 Elsevier Science 🌐 French ⚖ 116 KB

2,5-Bis(chloromethyl)pyrazine reacted with sodium alkoxide to give unexpected 2-dialkoxymethyl-5-methylpyrazine along with normal substitution product, 2,5-bis(alkoxymethyl)pyrazine. The reaction of 2,3,5,6-tetrakis(chloromethyl)pyrazine with sodium alkoxide afforded similar results to yield 2,6-bis