𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Investigations on basic aspects of fast atom bombardment mass spectrometry: Matrix effects, sample effects, sensitivity and quantification

✍ Scribed by W. D. Lehmann; M. Kessler; W. A. König

Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
502 KB
Volume
11
Category
Article
ISSN
1076-5174

No coin nor oath required. For personal study only.

✦ Synopsis

Basic aspects of fast atom bombardment mass spectrometry such as matrix effects, discriminatory effects between positive and negative ion formation, sensitivity, and isotope dilution have been investigated using oligopeptides and amino acid derivatives as model compounds. The matrix selected was found to have a decisive influence on the sensitivity of fast atom bombardment. Acidic and basic properties of the samples could be correlated with different ionization efficiencies in positive or negative ion formation. With respect to sensitivity, a roughly linear relation between signal intensity and sample amount was observed in the range of lng to 10 pg of sample. Nanogram amounts of samples could be detected by fast atom bombardment mass spectrometry. Finally, the suitability of fast atom bombardment for quantitative investigations is proven by the investigation of isotopically labelled mixtures.

📜 SIMILAR VOLUMES

Matrix effects on the fast atom bombardm
Matrix effects on the fast atom bombardment mass spectra of palladium complexes
✍ Larry M. Mallis; William J. Scott 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 360 KB

In an attempt to identify and characterize the intermediates involved in multi-step palladium catalyzed coupling reactions, under fast atom bombardment (FAB) conditions, the selection of a matrix to enhance ion formation without degrading the palladium complex is critical. In general, it is observed

Mass spectrometry of basic aluminum sucr
Mass spectrometry of basic aluminum sucrose octasulfate using fast atom bombardment with a saturated tetramethylammonium ion sample matrix
✍ Randall J. Baker 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 English ⚖ 224 KB

A fast atom bombardment method to produce stable molecular cations of sucrose octasulfate8-is described. The technique centers on ion exchange of the nonvolatile inorganic aluminum hydroxide cations for more volatile organic tetramethylammonium ions.