Long-term potentiation (LTP) or long-term depression (LTD) can be produced in the dentate gyrus (DG) of the hippocampus with high-or low-frequency stimulation trains, respectively. Although LTP can be elicited in a variety of preparations, we know of no reports of LTD unaccompanied by seizure activi
Investigations of the protein synthesis dependency of mGluR-induced long-term depression in the dentate gyrus of freely moving rats
β Scribed by Katja Naie; Denise Manahan-Vaughan
- Book ID
- 116784397
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 418 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0028-3908
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The ability of the perforant path/dentate granule cell synapse of the hippocampal formation to establish and maintain enhanced levels of synaptic transmission in response to tetanization (longterm potentiation, LTP) was investigated in freely moving rats at 15, 30, and 90 days of age. Measures of 1)
## Abstract This report examines the inductive mechanism involved in longβterm heterosynaptic depression (LTD) in the dentate gyrus of anaesthetized rats. Associative and nonβassociative stimulus protocols were implemented, using the ipsilateral medial and lateral perforant path inputs to the denta