Orexin-1 receptor mediates long-term potentiation in the dentate gyrus area of freely moving rats
β Scribed by Esmaeil Akbari; Fereshteh Motamedi; Farzaneh Ghiafeh Davoodi; Maryam Noorbakhshnia; Elham Ghanbarian
- Book ID
- 116286039
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 595 KB
- Volume
- 216
- Category
- Article
- ISSN
- 0166-4328
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The ability of the perforant path/dentate granule cell synapse of the hippocampal formation to establish and maintain enhanced levels of synaptic transmission in response to tetanization (longterm potentiation, LTP) was investigated in freely moving rats at 15, 30, and 90 days of age. Measures of 1)
Long-term potentiation (LTP) or long-term depression (LTD) can be produced in the dentate gyrus (DG) of the hippocampus with high-or low-frequency stimulation trains, respectively. Although LTP can be elicited in a variety of preparations, we know of no reports of LTD unaccompanied by seizure activi