Investigation on solvent hydrogen transfer during the catalytic deuteration of N-acetyl-3,5-di-iodo-L-tyrosineamide

✍ Scribed by J. Oehlke; H. Niedrich; H.-J. Zöpfl; P. Franke

• Publisher: John Wiley and Sons
• Year: 1989
• Tongue: French
• Weight: 319 KB
• Volume: 27
• Category: Article
• ISSN: 0022-2135
• DOI: 10.1002/jlcr.2580270802

✦ Synopsis

amide solvent hydrogen was incorporated instead of deuterium up to an order of 70%. The major part of the solvent hydrogen was shown to be introduced into the reaction product independently of the dilution of the reacting gas. This direct transfer depends on type of solvent and catalyst and on the catalyst-to-substrate ratio in the same manner as found from deuterations of 4-halogenated phenylalanine derivatives and dehydroproline. The distribution of deuterium in the reaction products was determined by mass spectrometry.

During the catalytic dehalodeuteration of N-acetyl-3,5-di-iodo-L-tyrosine