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Effects of catalyst pretreatment and additives on the hydrogen incorporation during the catalytic deuteration of N-acetyl-di-iodotyrosineamide

✍ Scribed by J. Oehlke; H. Niedrich; H.-J. Zöpfl; P. Franke

Publisher: John Wiley and Sons
Year: 1990
Tongue: French
Weight: 294 KB
Volume: 28
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580280404

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✦ Synopsis

Abstract

The influence of the mode of presaturating the catalyst and of different inhibiting agents on the catalytic deuteration of N‐acetyl‐3,5‐di‐iodo‐L‐tyrosineamide was investigated in order to derive conclusions for optimizing peptide tritiations. Reactions of the activated catalyst with solvent and substrate can be inhibited independently. The exchange of the catalyst‐bound deuterium against hydrogen from solvent is inhibited by the substrate itself and by addition of 1,3‐di‐chlorobenzene. The dehalogenation reaction and the unspecific exchange of carbon‐bound hydrogen of the substrate are inhibited preferably by thioglycolic acid, iodide and by the triethyl‐ammonium ion.

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Investigation on solvent hydrogen transf

Investigation on solvent hydrogen transfer during the catalytic deuteration of N-acetyl-3,5-di-iodo-L-tyrosineamide

✍ J. Oehlke; H. Niedrich; H.-J. Zöpfl; P. Franke 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 French ⚖ 319 KB

amide solvent hydrogen was incorporated instead of deuterium up to an order of 70%. The major part of the solvent hydrogen was shown to be introduced into the reaction product independently of the dilution of the reacting gas. This direct transfer depends on type of solvent and catalyst and on the c