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Investigation of unknown related substances in commercial erythromycin samples with liquid chromatography/mass spectrometry

✍ Scribed by Cindy Govaerts; Hezekiah Kibet Chepkwony; Ann Van Schepdael; Eugène Roets; Jos Hoogmartens

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
142 KB
Volume
14
Category
Article
ISSN
0951-4198

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✦ Synopsis

A selective reversed phase liquid chromatography/mass spectrometry (LC/MS(n)) method is described for the identification of erythromycin impurities and related substances in commercial erythromycin samples. Mass spectral data are acquired on a LCQ ion trap mass spectrometer equipped with an electrospray interface operated in positive ion mode. The LCQ is ideally suited for identification of impurities and related substances because it provides on-line LC/MS(n) capability. Compared with UV detection, this hyphenated LC/MS(n) technique provides as a main advantage efficient identification of novel substances without time-consuming isolation and purification procedures. Using this method four novel related substances were identified in commercial samples.

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