Investigation of the urinary excretion of pethidine and five of its metabolites in man using selected ion monitoring

✍ Scribed by Claes Lindberg; Ulf Bondesson; Per Hartvig

• Publisher: John Wiley and Sons
• Year: 1980
• Tongue: English
• Weight: 471 KB
• Volume: 7
• Category: Article
• ISSN: 1076-5174
• DOI: 10.1002/bms.1200070210

✦ Synopsis

The urinary excretion in man of pethidine and five of its metabolites (norpethidine, pethidinic acid, norpethidinic acid, p-hydroxypethidine and pethidine N-oxide) after a single intramuscular dose has been investigated using analytical procedures based on selected ion monitoring. New methods for the determination of p-hydroxypethidine and pethidine N-oxide have been developed, and the selectivity and sensitivity of the procedures are discussed. Only some 5% of the administered dose was excreted as unchanged pethidine. The mean urinary excretion of norpethidine was 16.4%. Pethidinic acid and norpethidinic acid constituted the major fraction of the dose excreted in urine. The total excretion of pethidinic acid and norpethidinic acid was 41.7 and 23.2%, respectively. Pethidine N-oxide constituted less than 0.5% of the excreted amount, and p-hydroxypethidine could only be detected in the urine of two of the patients. A mean total recovery of about 90% of the dose was found in urine as pethidine and the five metabolites.