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Investigation of the role of cytochrome P450 2B4 active site residues in substrate metabolism based on crystal structures of the ligand-bound enzyme

✍ Scribed by Cynthia E. Hernandez; Santosh Kumar; Hong Liu; James R. Halpert


Book ID
116177698
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
566 KB
Volume
455
Category
Article
ISSN
0003-9861

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## Abstract A human lymphoblastoid cell line stably expressing a human cytochrome P4501A2 cDNA was developed. This recombinant cell line displayed P4501A2 protein and estradiol2‐hydroxylase activity, neither of which was detected in the parental cell line. The recombinant cell line was also approxi