Investigation of the induction protocol for radiation-induced myeloid leukaemia
β Scribed by A. Riches; I. Doherty; M. Hepburn; C. Briscoe
- Book ID
- 113238774
- Publisher
- Elsevier Science
- Year
- 1986
- Tongue
- English
- Weight
- 45 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0145-2126
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Acute myeloid leukaemias (AML) arising in irradiated CBA/H mice frequently have breakpoints in the F region of chromosome 2. The closely linked cytokine genes interleukin (/L)-/a and p map to this region, and the p gene is deregulated in some AMLs. Using pulsed-field gel electrophoresis techniques,
## Abstract A cloned line of myeloid leukemic cells can be induced by the alkylating agent nitrosoguanidine for two macrophageβ and granulocyteβinducing (MGI) activities. One activity, MGIβ1, induced the formation of macrophage and granulocyte colonies from normal myeloblasts. Another activity, MGI