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Investigation of the anti-inflammatory and analgesic activity of 2-substituted 1-aryl-6-carboxy(carbethoxy)-7-methyl-4-oxo-1, 4-dihydropyrido[2,3-d]pyrimidines

✍ Scribed by V. É. Kolla; A. B. Deyanov; F. Ya. Nazmetdinov; Z. N. Kashina; L. P. Drovosekova


Book ID
112408762
Publisher
Springer
Year
1993
Tongue
English
Weight
147 KB
Volume
27
Category
Article
ISSN
0091-150X

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Synthesis and properties of 2-substitute
✍ L. M. Demina; M. Yu. Gavrilov; M. I. Vakhrin; M. E. Konshin 📂 Article 📅 1991 🏛 Springer US 🌐 English ⚖ 388 KB

Cyclization of 2- (N-acetyl-N-arylamino)nicotinonitriles in the presence of dry HCI gave 1-aryl-2-methyl-4-oxo-l,4-dihydropyrido[2,3-d]pyrimidines. It was shown that they are acylated by acetic anhydride, aroyl chlorides, and phenyl isocyanate at the methyl group and that with benzaldehyde they give