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Investigation of proton pump inhibitors binding with bovine serum albumin and their relationship to molecular structure

✍ Scribed by Yuping Zhang; Shuyun Shi; Mijun Peng


Book ID
113721149
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
446 KB
Volume
132
Category
Article
ISSN
0022-2313

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The binding constants and the number of binding sites for the binding of 11 sulfonamide and seven penicillin derivatives to bovine serum albumin were determined using a fluorescence probe method. The results demonstrate that these drugs bind to hydrophobic sites on the serum albumin. The binding aff