## Abstract Mutations in LRRK2 are the single most common known cause of Parkinson's disease (PD). Two new PD patients with LRRK2 mutation were identified from a cohort with extensive postmortem assessment. One of these patients harbors the R793M mutation and presented with the typical clinical and
β¦ LIBER β¦
Investigation of leucine-rich repeat kinase 2 : Enzymological properties and novel assays
β Scribed by Vasanti S. Anand; Laurie J. Reichling; Kerri Lipinski; Wayne Stochaj; Weili Duan; Kerry Kelleher; Pooja Pungaliya; Eugene L. Brown; Peter H. Reinhart; Richard Somberg; Warren D. Hirst; Steven M. Riddle; Steven P. Braithwaite
- Book ID
- 111312746
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 539 KB
- Volume
- 276
- Category
- Article
- ISSN
- 1432-1327
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## Abstract Mutations in the __leucineβrich repeat kinase 2__ (__LRRK2__) gene are the leading cause of genetically inherited Parkinson's disease (PD). Although this multidomain protein has been shown to have both GTPase and kinase activities through the Roc and MAPKKK domains, respectively, the pr