𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Investigation of keratinocyte regulation of collagen I synthesis by dermal fibroblasts in a simple in vitro model

✍ Scribed by C.A. Harrison; F. Gossiel; A.J. Bullock; T. Sun; A. Blumsohn; S. Mac Neil

Book ID
108668577
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
353 KB
Volume
154
Category
Article
ISSN
0007-0963

No coin nor oath required. For personal study only.

πŸ“œ SIMILAR VOLUMES

Uncoordinate expressions of type I and I
Uncoordinate expressions of type I and III collagens, collagenase and tissue inhibitor of matrix metalloproteinase 1 along in vitro proliferative life span of human skin fibroblasts: Regulation by all-trans retinoic acid.
✍ ValΓ©rie Bizot-Foulon; Brigitte Bouchard; William Hornebeck; Louis Dubertret; Bri πŸ“‚ Article πŸ“… 1995 πŸ› Elsevier Science 🌐 English βš– 452 KB

In vitro human skin fibroblasts aging was characterized by a continuous increase of collagenase mRNA levels. On the contrary, TIMP‐1 mRNA level decreased only at late passages (> 65% of proliferative life span). Type I and III mRNA levels showed a high variability depending on cell strains studied.

Transfer of proΞ±2(I) cDNA into cells of
Transfer of proΞ±2(I) cDNA into cells of a murine model of human Osteogenesis Imperfecta restores synthesis of type I collagen comprised of Ξ±1(I) and Ξ±2(I) heterotrimers in vitro and in vivo
✍ Christopher Niyibizi; Patrick Smith; Zhibao Mi; Charlotte L. Phillips; Paul Robb πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons 🌐 English βš– 197 KB

## Abstract The __oim__ mouse is a model of human Osteogenesis Imperfecta (OI) that has deficient synthesis of proΞ±2(I) chains. Cells isolated from __oim__ mice synthesize Ξ±1(I) collagen homotrimers that accumulate in tissues. To explore the feasibility of gene therapy for OI, a murine proΞ±2(I) cDN