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Investigation of HLA class I downregulation in breast cancer by RT-PCR

✍ Scribed by Giulio Lelio Palmisano; Maria Pia Pistillo; Paolo Capanni; Cinzia Pera; Guido Nicolò; Sandra Salvi; Luisa Perdelli; Gennaro Pasciucco; Giovanni Battista Ferrara

Book ID
117414615
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
280 KB
Volume
62
Category
Article
ISSN
0198-8859

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Loss of surface expression of class I major histocompatibility antigens is commonly observed in malignant tumors and has been considered one of the mechanisms for escape from cytotoxic T cells. However, natural killer cells kill cells lacking HLA class I antigens. In the present study, we characteri