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Investigating the effects of positive charge and hydrophobicity on the cell selectivity, mechanism of action and anti-inflammatory activity of a Trp-rich antimicrobial peptide indolicidin

✍ Scribed by Yong Hai Nan; Ka Hyon Park; Yoonkyung Park; Young Jin Jeon; Yangmee Kim; Il-Seon Park; Kyung-Soo Hahm; Song Yub Shin


Book ID
109331483
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
448 KB
Volume
292
Category
Article
ISSN
0378-1097

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Effects of dimerization of the cell-pene
✍ Wan Long Zhu; Song Yub Shin 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 298 KB

## Abstract The cell‐penetrating peptide Tat (48–60) (GRKKRRQRRRPPQ) derived from HIV‐1 Tat protein showed potent antibacterial activity (MIC: 2–8 µM). To investigate the effect of dimerization of Tat (48–60) analog, [Tat(W): GRKKRRQRRRPWQ‐NH~2~], on antimicrobial activity and mechanism of bacteric