✦ LIBER ✦

Investigating genomic imprinting and susceptibility to insulin-dependent diabetes mellitus: An epidemiologic approach

✍ Scribed by Bridget J. McCarthy; Dr. Janice S. Dorman; Christopher E. Aston; G. P. Vogler

Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 530 KB
Volume: 8
Category: Article
ISSN: 0741-0395
DOI: 10.1002/gepi.1370080304

No coin nor oath required. For personal study only.

✦ Synopsis

Children of fathers with insulin-dependent diabetes mellitus (IDDM) are at greater risk of developing the disease than are children of IDDM mothers, reasons for which are currently unknown. To explore the possibility that genomic imprinting contributes to this phenomenon, 1,774 families with at least one IDDM child diagnosed before the age of 17 years and between 1950 and 198 I from the Children's Hospital at Pittsburgh IDDM Registry were evaluated. Approximately I % of the mothers and 2.9% of the fathers were reported to have IDDM diagnosed before the age of 36 years (P 0.05). These data are not consistent with the genomic imprinting hypothesis and suggest that other genetic and/or environmental factors contribute to the increased risk for children of IDDM fathers.

📜 SIMILAR VOLUMES

The genetic susceptibility to insulin-de

The genetic susceptibility to insulin-dependent diabetes mellitus: Combined segregation and linkage analysis

✍ Dr. A. Green; A. Svejgaard; P. Platz; L. P. Ryder; B. K. Jakobsen; N. E. Morton; 📂 Article 📅 1985 🏛 John Wiley and Sons 🌐 English ⚖ 933 KB

We report a combined segregation and linkage analysis of a Danish sample of 2 16 insulin-dependent diabetes mellitus (IDDM) nuclear families: of these 2 16, twenty multiplex families were haplotyped regarding HLA-DR and -B markers. The analysis was conducted using the computer program COMBIN, which

No evidence for linkage between an insul

No evidence for linkage between an insulin-dependent diabetes mellitus-susceptibility locus and immunoglobulin loci KM or GM

✍ Dr. L. Leigh Field; Alisa Goldstein; M. Anne Spence; C. E. Anderson; David L. Ri 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 English ⚖ 507 KB

We studied 52 families having more than one member affected with insulindependent diabetes mellitus (IDDM) for linkage of an IDDM-susceptibility locus to the immunoglobulin loci KM and GM. Linkage was analyzed by the LOD score method using single-locus recessive and dominant models of IDDM inheritan

Molecular properties of HLA-DQ alleles c

Molecular properties of HLA-DQ alleles conferring susceptibility to or protection from insulin-dependent diabetes mellitus: Keys to the fate of islet ?-cells

✍ Moustakas, Antonis K. ;Papadopoulos, George K. 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 275 KB

Linkage of rheumatoid arthritis to insul

Linkage of rheumatoid arthritis to insulin-dependent diabetes mellitus loci: Evidence supporting a hypothesis for the existence of common autoimmune susceptibility loci

✍ Anne Myerscough; Sally John; Jennifer H. Barrett; William E. R. Ollier; Jane Wor 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 63 KB 👁 2 views

Case history notes designed as an aid to

Case history notes designed as an aid to professional education. Metabolic cataract causing loss of vision in newly diagnosed insulin-dependent diabetes mellitus

✍ Chalmers, J ;Herlihy, OH ;Macdonald, M ;Campbell, W 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 825 KB

## Abstract Loss of vision is a worrying symptom for any diabetic patient, particularly in young diabetic subjects with poor control. Once osmotic lens change has been excluded, patients presenting with recent changes in their vision should have careful ophthalmological assessment. In this case, a